Additionally, the germline Gα 11 hypermorphic variant, p.Ile62Val, identified in an N-ethyl-N-nitrosourea generated mouse, which is a model for ADH2, and the somatic constitutively activating mutations in Gα 11 identified in patients with uveal melanoma, also affect the interdomain interface (18, 32, 33). This evidence concerns the gene DRC4 and uveal melanoma.