During part 2 and the expansion part (N = 61), the most common TRAEs occurred in more than 30% of patients were increased AST (31patients, 50.8%), fatigue (27 patients, 44.3%), nausea and decreased appetite (26 patients, 42.6% each), increased ALT (23 patients, 37.7%), neutropenia and anemia (21 patients, 34.4% each), hypophosphatemia (20 patients, 32.8%), vomiting and thrombocytopenia (19 patients, 31.1% each). The gene discussed is GPT; the disease is Decreased total neutrophil count.