Genes downregulated in KO cells and upregulated in rescue cells included urokinase-type plasminogen activator PLAU (deficiency in mouse models increases seizure susceptibility [53]), the glycoprotein GALNT7 (upregulation of which has been found to promote glioma cell invasion [45]) and the brain tumor gene MYBL1 (that has been shown to be regulated by O-linked N-acetylglucosamine [42]. Here, GALNT7 is linked to central nervous system cancer.