Lsm11 binds FLASH (11), forming a platform for the recruitment of the Histone pre-mRNA Cleavage Complex (HCC), an assembly of 4 major polyadenylation factors: symplekin, CPSF100, CPSF73 and CstF64 (15), with CPSF73 acting as the 3′ endonuclease (23,38,73). This evidence concerns the gene SYMPK and hepatocellular carcinoma.