However, clinical studies have shown that the PGE2 pathway is strongly induced in both pediatric and adult IBD patients, and PGE2 metabolites are reliable biomarkers of intestinal inflammation (Arai et al., 2014; Hagiwara et al., 2017), indicating a general involvement of this pathway in common forms of IBD beyond rare diseases such as IL-10 deficiency. This evidence concerns the gene IL10 and hyperinsulinemic hypoglycemia, familial, 4.