Compelling evidence in support of an involvement of IL-10 in human intestinal inflammation comes from clinical observations that rare loss-of-function mutations in the IL10, IL10RA, or IL10RB genes lead to very-early-onset or infantile IBD with severe phenotypes (Glocker et al., 2010; Glocker et al., 2009; Glocker et al., 2011; Moran et al., 2013). Here, IL10 is linked to inflammatory bowel disease.