To study the impact of IL-10 on the inflammatory and microbicidal activities of Mφs and how alterations in IL-10 signaling may contribute to IBD, we generated an induced pluripotent stem cell (iPSC) line from an IBD patient harboring a homozygous mutation in the IL10RB gene predicted to introduce a premature stop codon resulting in nonfunctional protein. The gene discussed is IL10RB; the disease is inflammatory bowel disease.