TSC2 and epilepsy: Patients who were in a refractory state for a longer period of time were more likely to have seizures with bilateral motor symptoms, to have a TSC2 mutation, to live in a group home or with a caregiver, to have severe impairment of daily functioning, to use a higher number of AEDs, and to have a history of epilepsy‐related events, particularly bilateral tonic‐clonic status epilepticus and fractures.