Since it is known that low/medium levels of ROS promote cell proliferation by activating several pathways, such as MAPKs and the phosphoinositide 3-kinase (PI3K)–AKT pathway,13 it is not surprising that cancer cells are characterised by sustained ROS production that supports their uncontrolled proliferation.124 The activation of oncogenic pathways enhances the production of intracellular ROS, which, in turn, leads to the activation of oncogenes in a vicious circle that boosts cell proliferation and drives aggressiveness of cancer cells, thus affecting the outcome in cancer patients. Here, AKT1 is linked to cancer.