The MYC family of transcription factors (CMYC, LMYC and NMYC) controls cell proliferation and apoptosis by regulating a large number of RNA polymerase I-, II- and III-dependent genes.137,138 MYC amplification is commonly observed in neuroblastoma and in breast, ovary, prostate and uterine cancers, while the CMYC-immunoglobulin translocation is a hallmark of Burkitt’s lymphoma.139. The gene discussed is MYC; the disease is Burkitt lymphoma.