The recently described hybrid metabolic phenotype, in which the Warburg effect and OXPHOS coexist, provides cancer cells with the ability to adapt their metabolism to different microenvironments.192 Mitochondrial ROS play a central role in this process, through the stabilisation of HIF-1α, which promotes glycolysis, and AMPK, which promotes OXPHOS and fatty acid β-oxidation. This evidence concerns the gene HIF1A and cancer.