Like RAS, MYC induces complex metabolic rewiring in cancer cells, which is achieved through the stimulation of glycolysis,140 mitochondrial biogenesis141 and glutaminolysis.142 Li et al.141 demonstrated that inducible expression of MYC in the B-cell line P493-6 increases mitochondrial mass and enhances the oxygen consumption rate, an indicator of ETC activity. Here, MYC is linked to cancer.