HIF1A and cancer: In line with this scenario, scavenging mitochondrial O2•– through MitoTEMPO blunted the activation of AKT, reverted the Warburg effect and induced death in melanoma cells.165 Moreover, Variar et al.166 observed that the mitochondria-targeted antioxidant Mito-CP enhances apoptotic cell death in a Burkitt’s lymphoma cell line by decreasing AKT activation and HIF-1α stabilisation under hypoxia, suggesting the possibility to block hypoxic adaptation in cancer cells by decreasing ROS generated by the ETC.