KRAS and colonic neoplasm: Oncogenic KRAS signalling promotes the catabolism of glutamine, which fuels the TCA cycle, by enhancing mitochondrial ROS generation, resulting in anchorage-independent growth of colon cancer cells126; interestingly, this effect appeared to be mediated by mitochondrial, but not cytosolic, ROS and a functional ETC was required for KRAS-driven lung tumorigenesis in vivo.