MYC and cancer: MYC overexpression is associated with an increased proliferation rate in breast cancer,152 and MYC amplification in luminal A breast cancer is associated with poor survival and resistance to endocrine therapy.153 Although these studies did not evaluate whether ROS are involved in the aggressiveness of MYC-driven breast cancer, it is known that high ROS levels are associated with resistance to endocrine therapy.154 The impact of MYC-driven ROS production on the clinical outcome of cancer needs to be further studied in the future.