These authors observed that mitochondria-localised AKT phosphorylates MICU1, a regulatory subunit of the mitochondrial calcium uniporter (MCU), resulting in the destabilisation of the MICU1–MICU2 heterodimer, thus leading to increased calcium influx in mitochondria.162 Decreased expression of MICU1 following its phosphorylation was associated with increased levels of mitochondrial ROS and enhanced in vivo growth of cancer cells. This evidence concerns the gene AKT1 and cancer.