MYC and sarcoma: The role of ROS production following MYC amplification is supported by the fact that exogenous antioxidants (vitamin C and Tiron) inhibited transformation of MYC-overexpressing NIH/3T3 fibroblasts.145 Moreover, blunting ROS through mitochondria-targeted vitamin E blocked the proliferation and induced cell death in osteogenic sarcoma cells.146