The B-cell lymphoma-2 (BCL-2) family includes several proteins that counteract intrinsic apoptosis by binding pro-apoptotic proteins along the IMM.182 Many tumour types, including breast cancer, prostate cancer, B-cell lymphomas and colorectal adenocarcinomas, display BCL-2 overexpression.182,183 Several lines of evidence suggest that the upregulation of BCL-2, besides directly blocking apoptosis, creates a pro-oxidant state that promotes cell survival. This evidence concerns the gene BCL2 and B-cell non-Hodgkin lymphoma.