MT-ND2 and cancer: In several cancer types, loss of supercomplex organisation may favour a metabolic switch towards the Warburg effect phenotype.82 Consistent with the central role of complex I in respirasome assembly, cancer cells with mutations in ND2 exhibit a glycolytic metabolic profile; interestingly, these cancer cells also exhibited increased metastatic potential.30 In addition, the downregulation of NDUFS1, another complex I subunit, is selected by antiangiogenic therapy in ovarian cancer, leading to a stable glycolytic phenotype and increased aggressiveness.83