Of these, sestrins promote autophagic catabolism via the AMPK–mTOR pathway and excessive nutrient uptake in cancer cells under stress.109 Expression of sestrins is linked to tumorigenesis and is downstream of the TP53, epidermal growth factor receptor (EGFR)–Ras and PI3K–AKT–LKB1 pathways. The gene discussed is TP53; the disease is cancer.