Thus, by identifying tumours with high rates of glucose consumption that are consequently more dependent on ACLY activity for glycolysis-fuelled lipogenesis, dosing regimes with lower drug concentrations could be implemented.34 Furthermore, structural studies focussing on characterising the protein domains of the ACLY tetramer have revealed novel hydrophobic regions near the citrate-binding site that have untapped potential for improving the drugability of ACLY.212. Here, ACLY is linked to neoplasm.