PIK3CA and cancer: Finally, there has been a resurgent interest in studying the role of dietary interventions in cancer therapy.76,222,223 For instance, it has been demonstrated that a low-carbohydrate ketogenic diet dramatically increases the efficiency of PI3K inhibitors and synergistically reduces the growth of PIK3CA-mutant tumours.76 Since humans can only obtain essential omega-3 and omega-6 FAs from the diet, it is tempting to speculate that dietary modifications based on lipid consumption could also have an impact on tumorigenesis.