On the other hand, epithelial markers including E-cadherin, cytokeratin 5/6 and β-catenin were strongly expressed in epithelioid, weakly in biphasic and absent in sarcomatoid mesothelioma samples.50 Taken together, these results suggest that in MPM, TGF-β acts both on MPM and immune cells, supporting tumour growth and aggressiveness. This evidence concerns the gene TGFB1 and neoplasm.