Although PKM2 is reported to be highly oncogenic in numerous cancers,14,15,30–33 there are several strands of evidence from cell lines and genetically modified mouse models of different cancers that PKM2 deletion has no effect on cancer.34,37,55–59 More specifically, a recent study suggests that PKM2 is redundant in a mouse model of PDAC (LSL-KrasG12D/+;Trp53flox/flox;Pdx-1-Cre (KP−/−C) mice).60 This seems counterintuitive to the large body of evidence supporting an oncogenic role of PKM2 described above. This evidence concerns the gene PDX1 and cancer.