It is widely known that mitochondrial fission and fusion balance is regulated by several key regulators, including MFN2, DNM1L, OPA1 and MFF.32–34 In our current research, we found that these regulators of mitochondrial dynamics showed differed metastatic potential in HCC, and that MFN1 is a leading downregulated gene in mitochondria dynamics closely associated with HCC metastasis. This evidence concerns the gene MFF and hepatocellular carcinoma.