ACSL4 and neoplasm: In clear contrast, the genes involved in FA desaturation (stearoyl-CoA desaturase, SCD5) and PUFA trafficking (fatty acid-binding protein 7, FABP7; acyl-CoA synthetase 4, ACSL4; phospholipase A2G2D, PLA2G2D) were upregulated in tumours with PI(18:0/20:3) accumulation (Fig. 4c).