FABPs are cytosolic proteins that can uptake external FAs and transport them to various subcellular compartments.35 FABP7 has a higher affinity for PUFAs than other FABP family proteins, and it sustains brain development by supplying PUFAs that are essential for this process.36 Since FABP7 knockdown in the breast cancer cells leads to the alteration of PI composition and the gene expressions of PD-1-related immune checkpoint pathway, targeting PUFA trafficking mediated by FABP7 is likely to enhance the effect of immune checkpoint inhibition. The gene discussed is PDCD1; the disease is breast carcinoma.