The accumulation of ROS will increase Ca2+ release from intracellular stores and cause massive ATP depletion, membrane oxidation and necrosis.36 ROS has a complex function in that it may also activate caspases, which are known to induce apoptosis.37 In gastric tumour cells cisplatin has been demonstrated to induce caspase-1, which in turn predicts apoptosis.38 The gene discussed is CASP1; the disease is gastric neoplasm.