BRAF and melanoma: It has been reported that dependence on glycolysis and a lack of functional mitochondrial respiration increases melanoma sensitivity to BRAF inhibitors44 and that an increased dependency on mitochondria for survival is a characteristic of acquired resistance to BRAF inhibitors.45 However, in some cases dependence on increased oxidative metabolism of resistant melanoma cells is associated with a switch from glucose to glutamine metabolism.45 Here we report a metabolic shift from glycolysis to mitochondrial activation in resistant cells via anaplerotic PC activity.