We observed that the gap closure is slower in BDH2–5–8F cells (Fig. 5a), and fewer BDH2–5–8F cells invaded the extracellular matrix gel in contrast with control cells (Fig. 5b), suggesting that higher expression of BDH2 attenuates the metastasis of NPC cells by reversing EMT. The gene discussed is BDH2; the disease is nasopharyngeal carcinoma.