GLS2 and cancer: The current finding is more logical when considering that GLS is frequently deregulated in cancer and silencing or inhibiting GLS decreases tumour growth in a number of models.4,30,31 Although the role of GLS2 in cancer remains unclear, GLS2 is a p53 target gene and seems to function in tumour suppression in some tissues.32 Considering the important function of glutamine in cancer cell proliferation and survival, restricting glutamine uptake presents an appealing method for treating cancer.