GLS and head and neck squamous cell carcinoma: Notably, c-MYC was recently reported to directly suppress miR-137; thus, MYC regulates ASCT2 in dual mechanisms, collectively contributing to ASCT2 upregulation (just as GLS expression is upregulated by MYC both directly and indirectly through the MYC-mediated inhibition of miR-23 expression, which in turn suppresses GLS translation).37 In addition, in a previous study, miR-137 promoter methylation (which should promote ASCT2 expression) was associated with the poor survival of HNSCC patients, which is in line with our findings.38