Notably, c-MYC was recently reported to directly suppress miR-137; thus, MYC regulates ASCT2 in dual mechanisms, collectively contributing to ASCT2 upregulation (just as GLS expression is upregulated by MYC both directly and indirectly through the MYC-mediated inhibition of miR-23 expression, which in turn suppresses GLS translation).37 In addition, in a previous study, miR-137 promoter methylation (which should promote ASCT2 expression) was associated with the poor survival of HNSCC patients, which is in line with our findings.38 Here, SLC1A5 is linked to head and neck squamous cell carcinoma.