PKD1 and familial pancreatic carcinoma: In addition, PKD1 acts as one of the reactive oxygen species (ROS)- sensing molecule in the tumour microenvironment, increases oxidative stress, ultimately resulting in pancreatic cancer progression.6 Therefore, we were interested to further investigate the PKD1 expression during PDAC development by using human PDAC tissue samples and molecular changes influenced by PKD1 expression that may contribute to pancreatic tumorigenesis.