PKD1 and neoplasm: Many signalling molecules are reported to play an essential role in the aberrant metabolic processes, but further studies are still required to develop effective treatment strategies targeting glucose metabolism.28 Several reports indicate an oncogenic role of the PKD1 protein in pancreatic cancer, but the mechanisms involved have not been sufficiently defined.5,29 Therefore, in this study, we report a novel role of PKD1 in rewiring of glucose metabolic network that drives favourable tumour microenvironment and oncogenic signalling pathways in pancreatic cancer cells.