Glucose transporter-1 (GLUT1) mediates cellular transport of glucose required for anaerobic metabolism in cancer cells.31 Oncogenic K-Ras mutation, a signature event in pancreatic cancer, induces GLUT1 expression resulting in anabolic glucose metabolism.32 Recent studies suggest the association of KRAS mutations with the increased PRKD1 promoter.8 Although a precise molecular mechanism of how PKD1 induces GLUT1 expression, is not illustrated in this paper, we speculate a functional link between the activation of PKD1 with the oncogenic KRAS mutations induced by GLUT1 expression. This evidence concerns the gene PRKD1 and familial pancreatic carcinoma.