PRKD1 and familial pancreatic carcinoma: Protein kinase D1 (PKD1), a serine–threonine kinase, is an important modulator of several kinase signal transduction pathways.4 PKD1 belongs to the PKD family and is the most studied protein  kinase among the three family members (PKD1, PKD2 and PKD3).4 Previous reports have suggested that PKD1 is involved in pancreatic cancer pathogenesis,5,6 but the underlying signalling mechanisms are largely unknown.