The exact same result was obtained separating the breast cancers between those positive and negative for p53 (p53 + and p53−, respectively), where 5-HTR2c was upregulated in p53 + , as compared with p53− cancer (Fig. 5d), while 5-HTR7 remained unaltered between the two groups (Fig. 5e). The gene discussed is TP53; the disease is breast cancer.