PDP1 and cancer: This compound induces cell growth arrest by inhibiting pyruvate dehydrogenase kinase (PDK) with consequent activation of PDH, thus promoting the entry of pyruvate into the TCA cycle.40 We also demonstrated that ACO2 expression affects glutamine addiction of MCF-7 cells, indicating that feeding TCA cycle with pyruvate and channelling it for aerobic oxidation in the presence of adequate ACO2 levels dislodge cancer cells from using glutamine for anaplerosis.