The CD68 + macrophages were more frequent while CD20 + B lymphocytes were the least.33 In this study, however, we observed that changes in the metabolic activity of the cancer cells, which is reflected by an increase in glutamine transport, derive specific components of immune cells, which were restricted to CD68 +, FOXP3 +  and CD20 + along with PD1 + cells. This evidence concerns the gene PDCD1 and cancer.