Furthermore, there is a link between the two mentioned hallmarks, as changes in the tumour cell metabolism can influence the component and function of the inflammatory infiltrates.21,32 This study showed that altered glutamine metabolism, which was detected by the overexpression of the key glutamine transporters (SLC1A5, SLC7A5 and SLC3A2) was significantly associated with the existence of specific subtypes of immune cells, namely CD68 + macrophages, FOXP3 + regulatory T cells (Tregs), CD20 + B lymphocytes and PD1 + lymphocytes along with its tumour-expressing ligand (PDL1). The gene discussed is SLC3A2; the disease is neoplasm.