The association between PD1/PDL1 and survival in BC is controversial.20,48–50 This study, however, showed that the co-expression of SLCs with PD1 or PDL1 was associated with shorter distant metastasis-free survival and breast cancer-specific survival, indicating that patients with BC show an increase in their amino acid metabolic activity that might influence poor outcome in PD1/PDL1 + tumours. The gene discussed is PDCD1; the disease is breast carcinoma.