The Ki-67 response was significantly lower in tumours with high HIF-1α expression [mean adjusted difference −2.5% (95% CI −0.4, -4.6%) p = 0.018], using an ANCOVA adjusting for baseline HIF-1α, baseline Ki-67, BMI and tumour grade (Fig. 1c, d). The gene discussed is HIF1A; the disease is neoplasm.