Nevertheless, similar observations have been made in the field of human prion diseases: the use of human PrP substrate for RT-QuIC analyses results in lower sensitivity and specificity compared to Syrian hamster or bank vole PrP for detecting PrPSc in peripheral tissues (e.g. cerebrospinal fluid and olfactory mucosa) of prion diseased patients103–107. The gene discussed is PRNP; the disease is prion disease.