Initially our studies were driven by epidemiologic data showing an association between diabetes and Alzheimer’s disease in humans so we focused on the hypothesis that greater diabetes-related neuropathology would exist in the brains of diabetic-susceptible NGR rats fed hiCHO diets compared with diabetic-resistant NGR rats fed the same diet, and that these distinctions would be enhanced by PFB as it protected against diabetes. This evidence concerns the gene KRT75 and early-onset autosomal dominant Alzheimer disease.