This was further supported by the fact that ASCL1, LMO1, and MYCN were each more highly expressed in the ADRN subtype of neuroblastoma cell lines corresponding to sympathetic progenitors, but less in cell lines of the MES subtype, which appear to retain features of earlier migratory neural crest cells (Supplementary Fig. 6a). This evidence concerns the gene MYCN and neuroblastoma.