Consistent with these findings, analysis of our previously established neuroblastoma zebrafish models30 demonstrated that mRNA expression levels of the zebrafish orthologues, namely ascl1a, lmo1, phox2bb, hand2, tbx2a, and isl1l, were higher in MYCN-induced tumors compared with the c-MYC-induced tumors (Supplementary Fig. 6b). Here, HAND2 is linked to neuroblastoma.