LMO1 and neuroblastoma: Because LMO1 lacks a DNA-binding domain, it cannot be a member of the ADRN CRC in neuroblastoma, but rather it serves as an essential transcriptional regulatory cofactor for formation of the autoregulatory loop that comprises the CRC, and the absence of LMO1 expression leads to decreased levels of each of the ADRN CRC transcription factors.