Given that ASCL1 is also a selective neuroblastoma dependency gene whose locus is bound by the CRC delineated by our prior work19, and whose product binds coordinately with the ADRN CRC members to enhancers controlling each of the CRC members and genes of the extended regulatory network, we propose that ASCL1 is also an essential transcription factor and member of the feed-forward autoregulatory loop that comprises the CRC in the ADRN subtype of neuroblastoma. The gene discussed is ASCL1; the disease is neuroblastoma.