However, ASCL1 overexpression did not rescue the cell growth inhibition caused by LMO1 knockdown (Supplementary Fig. 7h–j), indicating that the effects of the CRC in maintaining neuroblastoma cell growth and survival depend on high levels of expression of each member of the CRC and the LMO1 CRC coregulator acting in concert. This evidence concerns the gene LMO1 and neuroblastoma.