Several features of inflammation showed a negative association, namely portal inflammation, portal lymphoid aggregates, plasma cell infiltrates, granulocytes, CD20 positive B-cells and CD4 positive T-cells, lobular granulocytes and histiocytes, chronic cholangitis, bile duct destruction, reactive Ito cells, CD3, CD4 and CD8 positive T-cells. The gene discussed is CD8A; the disease is chronic cholangitis.