Besides, although we identified the eQTL associations between rs12415800 and expression of SIRT1 in the brain and blood tissues, we noticed that SNPs in high LD with rs12415800 also spanned additional genes, such as CTNNA3, DNAJC12, HERC4, and MYPN. Although the functions of those genes in MDD pathogenesis are less investigated compared with SIRT1, we cannot exclude the possibilities that those genes may also be relevant to MDD genetic risk and participate in its pathogenesis. The gene discussed is HERC4; the disease is major depressive disorder.