CNR1 and infection: Transient increases in serum ALT or AST levels were noted in rHB29- or rHB2912aaNSs-immunized animals after virus challenge (SI Appendix, Fig. S2 C and D), while both ALT and AST levels rose steadily over the course of infection in the blood samples taken from the CB1/2014 challenge only animals (SI Appendix, Fig. S2 C and D).