NOD2 and colorectal neoplasm: Evidence from experimental studies in mice investigating the role of Nod2 in colorectal tumour risk has also been inconsistent.49–51 The recent analyses in East Asia,40 the GECCO, CORECT and CCFR consortia41 and of five UK studies and a further 10 from the COGENT consortium47 identified new associations in the major histocompatibility region.