After credibility assessment and validation, we identified a total of 12 genetic loci credibly associated with CRC risk, of which 6 loci (MUTYH, SMAD7, 8q24, 8q23.3, 11q23.1, 20p12.3) were also classified as credibly associated with CRC risk in the previous field synopses and the other 6 loci (TGFB1, TERT, CDH1, RHPN2, BMP2 and 10p14) are novel findings as they have not been assessed or reported as credible risk loci in the previous field synopses. The gene discussed is SMAD7; the disease is colorectal carcinoma.