Bioinformatics analysis showed that PPARγ and its ligands have been found to block proinflammatory genes in colon cancer cell lines, activated macrophages and monocytes.48PPARγ is also involved in lipid metabolism, adipocyte differentiation, and glucose homeostasis and insulin sensitivity.48 A less-credible positive association also reported one variant (rs2066847) in NOD2 gene; however, this association was not replicated. This evidence concerns the gene NOD2 and colonic neoplasm.