Cluster eight is characterized by cardiovascular complications, and three of the top ranking genes for this cluster have been associated with LDL peak particle diameter (THBS4; Rudkowska et al., 2015), abdominal aortic aneurysm (ERG; Jones et al., 2017), pulse pressure (ERG; Warren et al., 2017), and diastolic blood pressure (PLCB1; Warren et al., 2017). This evidence concerns the gene THBS4 and abdominal aortic aneurysm.