PLP1 and Pelizeaus-Merzbacher spectrum disorder: In aggregate, 159 join-points from 124 unrelated patients with PMD are available for breakpoint junction data meta-analysis at this PLP1 locus; 61 individuals, i.e., almost half, had a CGR with more than one CNV and showed evidence that multiple copy number variant states were generated in the same structural-variation event, potentially due to iterative TS [14, 20, 23, 31, 34, 35].