In the Drosophila AD model, Lang et al. [48] reported that dZIP1 knockdown of Aβ42 flies led to a longer lifespan (Fig. 3d), a stronger climbing ability and fewer brain vacuoles than the control of Aβ42 flies, whereas dZIP1 overexpression exacerbated the AD-like symptoms of Aβ42 flies. Here, DZIP1 is linked to Alzheimer disease.