To further confirm the relationship among METTL3, DDP resistance, and tumor metastasis in human lung cancer, we generated an A549 cell line with the stable co-expression of METTL3 with a control vector (METTL3Vector), shMALAT1 (METTL3shMALAT1), shYTHDF3 (METTL3shYTHDF3), and shYAP (METTL3shYap). Here, METTL3 is linked to lung carcinoma.