In order to reverse chemical resistance and reduce metastasis of lung cancer, we demonstrated the following results in the present study (1) the levels of m6A modification of YAP are increased by METTL3, (2) METTL3 directly enhances the translation of YAP by recruiting YTHDF1/3 and eIF3b to the translation initiation complex, (3) the stability of lncMALAT1 is increased due to the enhanced m6A modification by METTL3, and (4) MALAT1 sponges miR-1914-3p to promote the invasion and metastasis of NSCLC cells via YAP. This evidence concerns the gene METTL3 and non-small cell lung carcinoma.