Recently, several studies have shown that various transcriptional factors, such as STAT1 [44], STAT3 [45], BRD4 [23], NF-kB [18], PI3K/AKT/mTOR [46], and MEK1/2/ERK1/2 [47], promoted PD-L1 transcription in cancer cells. This evidence concerns the gene MAP2K1 and cancer.