To elucidate whether the RAGE ligands or sRAGE were changed by anti-TB treatment, we estimated the circulating plasma levels of AGE, sRAGE, S100A12 and HMGB-1 in TB-DM and TB at baseline (pre-treatment), during treatment (2nd month) and at the completion of ATT (6th month). Here, HMGB1 is linked to tuberculosis.