To elucidate the relationship between the circulating plasma levels of RAGE ligands and disease severity in TB-DM, based on chest X-ray we compared plasma levels of AGE, sRAGE, S100A12 and HMGB-1 in TB-DM and TB study participants with unilateral vs bilateral disease and cavitary vs non-cavitary disease. This evidence concerns the gene S100A12 and diabetes mellitus.