S100A12 and diabetes mellitus: As shown in Fig. 2, AGE (Geo Mean of 4.88 pg/ml in TB-DM vs 2.52 pg/ml in TB); sRAGE (Geo Mean 635.2 pg/ml in TB-DM vs 425.6 pg/ml in TB) and S100A12 (Geo Mean 2018 pg/ml in TB-DM vs 1073 pg/ml in TB) levels remained significantly increased in TB-DM compared to TB at 2 months treatment.