NLRP3 and diabetes mellitus: Since (i) aldosterone has pro-oxidative and pro-inflammatory effects, (ii) aldosterone-induced ROS generation is linked to vascular dysfunction in diabetes [13,14,18,34,35]; and (iii) ROS are one of the main activators of NLRP3 inflammasome [18,36], we tested the effect of the selective inhibitor of the NLRP3 receptor on ROS generation in mesenteric arteries taken from mice with diabetes, as well as in arteries taken from control mice that were stimulated with aldosterone.