In particular, it shows that (i) db/db mice display increased levels of aldosterone as well as increased caspase-1 activation and IL-1β production in mesenteric arteries; (ii) spironolactone, a MR antagonist, prevents these events; (iii) NLRP3 inhibition in vitro and in vivo reverses endothelial dysfunction in db/db mice. The gene discussed is NLRP3; the disease is endothelial dysfunction.