Mechanisms of action included the inhibition of NF-κB activation, induction of the cleavage of caspase-3/9 and Bax/Bcl2 ratio in favor of apoptosis, and inhibition of the expression of cyclin D1, MMP-9, and vascular endothelial growth factor (VEGF) that refers to cancer cell proliferation, metastasis, and angiogenesis, respectively. This evidence concerns the gene BCL2 and cancer.