TP53 and ovarian carcinoma: It was shown that black tea pigments exerted potent inhibitory activity against cisplatin-resistant ovarian cancer cells, while they were less cytotoxic to normal ovarian cells, with the mechanisms involving the induction of G1 cell cycle arrest by down-regulating cyclin-dependent kinase (CDK) 2, CDK4, and cyclin E1, and mediating apoptosis through p53-dependent, ATM/Chk/p53, Akt, and MAPK pathways [10].