The nanoparticles transformed the redox status, inhibited the Nrf2 (nuclear factor erythroid 2-related factor 2) activation, reduced the phosphorylation of IκB, blocked the nuclear translocation of NF-κB, and suppressed the NF-κB-dependent anti-apoptotic proteins Bcl2 and Akt, all of which triggered the onset of apoptosis in cancer cells [116]. The gene discussed is BCL2; the disease is cancer.