A number of PMTs are considered attractive therapeutic targets [2,3,4]: EZH2, the catalytic subunit of the polycomb repressive complex 2 (PRC2), tri-methylates lysine 27 of histone 3 (H3K27), and oncogenic hyper-trimethylation of H3K27 is driven by overexpression or activating mutations of EZH2 in lymphoma. This evidence concerns the gene EZH2 and lymphoma.