Interestingly, while POPDC3 mutations have also been linked to LGMD, the biopsies of patients carrying any one of the three identified POPDC3 mutations do not display aberrant membrane localization of the mutant protein, nor were there any alterations observed in POPDC1 or POPDC2 [17] suggesting that differences exist between the pathogenic processes that are trigged by different POPDC isoforms. Here, POPDC1 is linked to limb-girdle muscular dystrophy.