In the current study, we firstly reported the novel finding that RC could inhibit tumor cell growth in vitro and in vivo and induce apoptotic and autophagic cell death through inhibiting the NF-κB and Akt/mTOR/P70S6K signaling pathways, which would contribute to the future development of RC as a new therapeutic agent for treating cancer. This evidence concerns the gene NFKB1 and neoplasm.