As thanatos-associated protein 10 (THAP10) is a nuclear protein that inhibits myeloid proliferation and promotes differentiation both in vitro and in vivo, AML1-ETO inhibits expression of the tumor suppressor THAP10 directly via epigenetic suppression of the THAP10 promoter and indirectly through transcriptional activation of miR-383 in t(8;21) AML, unveiling a novel epigenetic mini-circuitry of AML1-ETO/THAP10/miR-383 [28]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.