RUNX1 and acute myeloid leukemia: Matsuura and colleagues [118], in order to explain the selective advantage for sex chromosome loss in t(8;21)-AML, used a transduction/transplantation assay where Runx1-Runx1t1 was expressed from a retroviral vector in βc-knockout bone marrow cells, which were then transplanted into irradiated wild-type recipient animals.