Results showed a total of 605 RUNX1T1 ceRNAs significantly enriched in gene ontology (GO) categories mainly associated with leukemia, suggesting the hypothesis that RUNX1T1 may also act as a miRNA sponge in t(8;21) AML, and contributing to explain the complex pattern of gene expression alterations observed in CBFL. This evidence concerns the gene RUNX1T1 and leukemia.