Recently, mutations in ASXL1 (additional sex combs like 1), ASXL2 (additional sex combs like 2), ZBTB7A (zinc finger and BTB domain conteining 7A), CCND2, and DHX15 (DEAH-box helicase 15) have been frequently identified in RUNX1–RUNX1T1 but not in CBFB–MYH11 AML patients [14,107]. Here, DHX15 is linked to acute myeloid leukemia.