RUNX1 and leukemia: A series of concomitant evidence in the CBFL proved the existence of a preleukemic phase confirmed by a prolonged latency observed in experimental models between the occurrence of RUNX1-RUNX1T1 CBF translocation and the development of overt leukemia [17,18], the persistence of CBFL translocations in normal HSC detected from patients in remission [19,20,21], and the maintenance of RUNX1-RUNX1T1 at diagnosis and at relapses.