RUNX1 and acute myeloid leukemia: Loss-of-function mutations in genes that regulate chromatin-modifying genes (ASXL1/2, EZH2, KDM6A, BCOR/BCORL1, EED, SETD2, KMT2D, KMT2C, and CREBBP) or in genes implicated in the cohesin complex (RAD21, SMC1A, SMC3, STAG2) were observed almost exclusively in RUNX1–RUNX1T1 AML.