Of note, GPR17, a modulator of oligodendroglial cell maturation [35], is linked to a significantly reduced expression of sorting nexin family member 27 (SNX27) in DS [36], which was demonstrated to impair oligodendroglial precursor cell (OPC) maturation, resulting in myelination deficits in Ts65Dn mice, a mouse model for DS [37]. The gene discussed is SNX27; the disease is Dravet syndrome.