FADS1 and coronary artery disorder: Other studies, including two prospective studies [56,57] (of which one relatively large cohort of 24,032 Swedish adults [57]) and a case-control study [58] found no significant association of SNPs in FADS1 or Δ5-desaturase activity (defined by the ratio of AA to dihomo-γ-linolenic acid) with risk of coronary artery disease or ischemic stroke.