IL1R1 and Anxiety: CeA GABAergic transmission plays a critical role in mediating ethanol and anxiety-like behaviors [32], and we have previously identified modulatory roles for several innate immune elements [including LPS (a TLR4 agonist, [33]), IL-1β, the IL-1R1 ligand, and IL-1ra (an endogenous IL-1R1 antagonist [34,35])] at mouse CeA GABAergic synapses.