In this context, we evaluated whether lonchocarpin, a chalcone isolated from Lonchocarpus sericeus, is able to inhibit the Wnt signaling pathway in human colorectal cancer cell lines RKO pBAR/Renilla stimulated with Wnt3a CM (conditioned medium) for 24 h and non-stimulated SW480 pBAR/Renilla (Figure 1A). This evidence concerns the gene WNT3A and colorectal cancer.