By reviewing the known genes involved in breast cancer metastasis [15,16,17] and our available MDA-MB-231 cell RNA-seq data [4], we identified synaptopodin 2 (SYNPO2), with a known function in metastasis, which showed the highest fold change (2.05-fold increase) in MDA-MB-231 cells after vitamin C treatment. This evidence concerns the gene SYNPO2 and breast cancer.