ADORA2A and Sepsis: Alternative splicing of the 5’UTR could play a crucial role in the post-transcriptional regulation of G protein-coupled receptors, including the modulation of translational efficiency, message stability, and subcellular localization, and differential expression of 5’UTR splice variants of the adenosine A2A receptor gene was shown in vitro in human stimulated granulocytes in sepsis patients compared to healthy volunteers [32].