Interestingly, among the identified downstream targets of PAX4 we have uncovered several immune modulators such as galectin-9 (Lgals9) and Reg3g, both of which are able to prevent/delay the apparition of hyperglycemia in the non-obese diabetic (NOD) mouse model of autoimmune diabetes correlating with decreased insulitis [91,92]. This evidence concerns the gene PAX4 and Hyperglycemia.