Next, we screened alteration of apoptosis-related protein levels by honokiol, and found that honokiol increased DR5 expression and decreased Mcl-1, survivin, and c-FLIP expression in renal carcinoma (Caki, ACHN and A498), lung carcinoma (A549), and cervical cancer (Hela) cells (Figure 2A,B). The gene discussed is CFLAR; the disease is lung carcinoma.