Mice with MTHFR gene variant (Mthfr+/-) or “mild Mthfr deficiency” showed impairment in short-term memory function, increased anxiety and disruption in choline metabolism in the cortex and the hippocampus during the first 10 months of life with a decrease in hippocampal Bdnf gene expression. This evidence concerns the gene MTHFR and hyperinsulinemic hypoglycemia, familial, 4.